Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation.

@article{Philippe2003AntiinflammatoryPO,
  title={Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation.},
  author={David Philippe and Laurent Dubuquoy and Herv{\'e} Groux and Val{\'e}rie Brun and Myriam Tran Van Chuo{\"i}-Mariot and Claire Gaveriaux-Ruff and J F Colombel and Brigitte Lina Kieffer and Pierre Desreumaux},
  journal={The Journal of clinical investigation},
  year={2003},
  volume={111 9},
  pages={
          1329-38
        }
}
The physiologic role of the mu opioid receptor (MOR) in gut nociception, motility, and secretion is well established. To evaluate whether MOR may also be involved in controlling gut inflammation, we first showed that subcutaneous administration of selective peripheral MOR agonists, named DALDA and DAMGO, significantly reduces inflammation in two experimental models of colitis induced by administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) or peripheral expansion of CD4(+) T cells in… Expand
Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice.
TLDR
BU08070 significantly reduced the severity of colitis in TNBS-treated mice compared with controls, suggesting that it is a potential therapeutic agent for inflammatory bowel diseases therapy. Expand
The putative role of endogenous and exogenous opiates in inflammatory bowel disease
TLDR
Findings not only demonstrate the therapeutic potential of drugs that target the MOR in IBD, but also that endogenous opiate may confer a measure of protection against inflammation. Expand
Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases.
TLDR
The results show a potent anti-inflammatory and antinociceptive effect of P-317 in mouse models of colitis upon activation of opioid receptors, and suggests that it is a promising drug candidate for future treatment of IBD. Expand
Mu opioid receptor expression is increased in inflammatory bowel diseases: implications for homeostatic intestinal inflammation
TLDR
Overexpressed in active IBD mucosa, MOR was significantly enhanced by cytokines and repressed by NFκB inhibitor in myeloid and lymphocytic cell lines, which suggests natural and/or synthetic opioid agonists could help to prevent overt pathological intestinal inflammation. Expand
Toll-like receptor 4 contributes to the inhibitory effect of morphine on colonic motility in vitro and in vivo
TLDR
This is the first report that morphine-induced inhibition of colonic peristalsis is alleviated by TLR4 antagonism, and it is concluded thatTLR4 may contribute to opioid-induced constipation. Expand
Contribution of opioid and neurotensin receptors in the anti‐inflammatory activity of PK20 hybrid compound in murine airways
TLDR
The activation of both the opioid and neurotensin receptors seems to be necessary to induce the full anti‐inflammatory activity of the hybrid compound. Expand
The involvement of nitric oxide in the enhanced expression of μ‐opioid receptors during intestinal inflammation in mice
TLDR
Results suggest that nitric oxide derived from the increased expression of iNOS is implicated in the enhanced effects of morphine and in the upregulation of MOR gene transcription observed during intestinal inflammation. Expand
Systemic Administration of Sialorphin Attenuates Experimental Colitis in Mice via Interaction With Mu and Kappa Opioid Receptors
TLDR
It is shown that indirect stimulation of opioid receptors by the blockade of NEP and APN is a promising pharmacological strategy for the treatment of IBD, and may become of greater importance than the use of classical opioid agonists. Expand
μ-Opioid receptor activation prevents acute hepatic inflammation and cell death
TLDR
Treatment with DAMGO was shown to prevent cell death in vitro in HepG2 cells in a MOR-dependent manner and to prevent concanavalin A- and CCl4-induced cellDeath in vivo, providing a possible explanation for the anti-inflammatory role of MOR activation in the liver. Expand
Peripheral Opioid Receptor Blockade Enhances Epithelial Damage in Piroxicam-Accelerated Colitis in IL-10-Deficient Mice
TLDR
It is shown that IL-10-deficient mice treated with piroxicam exhibited significant alterations of the intestinal barrier function, including permeability, inflammation-related bioactive lipid mediators, and mucosal CD4+ T lymphocyte subsets, which substantially contributes to the protection of the physical integrity of the epithelial barrier. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 104 REFERENCES
Inflammation enhances mu-opioid receptor transcription and expression in mice intestine.
TLDR
It is shown that intestinal inflammation enhances the transcription and translation of mu-OR mRNA, thus explaining the increased potency ofmu-opioids during inflammation. Expand
Immunomodulatory action of class μ, δ- and κ-opioid receptor agonists in mice
TLDR
The results suggest that there are three classes of opioid receptors on T-lymphocytes and that all these receptor classes are involved in the stimulation of concanavalin A-induced proliferation. Expand
Involvement of Central μ- but Not δ- or κ-Opioid Receptors in Immunomodulation
TLDR
Results from the present study indicate that the immunomodulatory effects of opioids can be attributed to interactions with the μ-opioid receptor. Expand
Involvement of central mu- but not delta- or kappa-opioid receptors in immunomodulation.
TLDR
Results from the present study indicate that the immunomodulatory effects of opioids can be attributed to interactions with the mu-opioid receptor. Expand
Immunomodulatory action of class mu-, delta- and kappa-opioid receptor agonists in mice.
TLDR
The results suggest that there are three classes of opioid receptors on T-lymphocytes and that all these receptor classes are involved in the stimulation of concanavalin A-induced proliferation. Expand
Effect of morphine on lipopolysaccharide-induced tumor necrosis factor-α production in vivo: involvement of the sympathetic nervous system
TLDR
It is concluded that systemic administration of morphine inhibits LPS-induced TNF-alpha production in vivo via 'classic' opioid receptors; (ii) this effect requires intact sympathetic outflow, and the increased incidence of bacterial and viral infections in opioid addicts is well documented. Expand
The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in BALB/cJ mice.
TLDR
The effect of naloxone could be ascribed to the removal of the regulatory effects exerted by endogenous opioid peptides, which could therefore activate T(H)2 and suppress T( H)1 cytokines. Expand
Abolition of morphine-immunosuppression in mice lacking the mu-opioid receptor gene.
TLDR
It is demonstrated that the MOR gene product represents a major molecular target for morphine action on the immune system, and implies that MOR-targeted therapeutic drugs that are developed for the treatment of pain or opiate addiction may concomitantly influence immune responses. Expand
Effects of mu-opioid receptor agonists on intestinal secretion and permeability during acute intestinal inflammation in mice.
TLDR
Investigation of acute intestinal inflammation shows that inflammation increases the inhibitory potency of mu-opioid receptor agonists on secretion and permeability, suggesting a sensitization of peripheral mu-OPioid receptors. Expand
Inhibition of leukotriene synthesis markedly accelerates healing in a rat model of inflammatory bowel disease.
TLDR
It is demonstrated that inhibition of leukotriene synthesis results in a marked acceleration of the healing of Colonic ulcers and resolution of colonic inflammation in this animal model of chronic colitis, consistent with the hypothesis thatLeukotrienes play an important role in the pathogenesis of intestinal inflammation. Expand
...
1
2
3
4
5
...