Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation.

@article{Guenzl2010AntiinflammatoryPO,
  title={Anti-inflammatory properties of the PI3K pathway are mediated by IL-10/DUSP regulation.},
  author={Philipp M. Guenzl and Kathrin Bauer and Eva Hainzl and Ulrich Matt and Barbara Dillinger and Benedikt Mahr and Sylvia Knapp and Bernd R. Binder and Gernot A. Schabbauer},
  journal={Journal of leukocyte biology},
  year={2010},
  volume={88 6},
  pages={1259-69}
}
Resolution of inflammation is an important hallmark in the course of infectious diseases. Dysregulated inflammatory responses may have detrimental consequences for the affected organism. Therefore, tight regulation of inflammation is indispensable. Among numerous modulatory signaling pathways, the PI3K/PTEN signaling pathway has been proposed recently to be involved in the regulation of innate immune reactions. Here, we attempted to elucidate molecular mechanisms that contribute to the… CONTINUE READING