Anti-inflammatory properties of exenatide in human pancreatic islets.

  title={Anti-inflammatory properties of exenatide in human pancreatic islets.},
  author={Sirlene R. Cechin and Ingrid P{\'e}rez-Alvarez and Elizabeth S. Fenjves and Ruth Damaris Molano and Antonello Pileggi and P-O Berggren and Camillo Ricordi and Ricardo Luis Pastori},
  journal={Cell transplantation},
  volume={21 4},
Exenatide is an analog of the incretin hormone glucagon-like peptide (GLP-1) that is used for the treatment of T2D for their metabolic effects. In addition to its insulinotropic effects, exenatide increases functional islet mass and improves their survival. Improved outcomes have been reported in recent clinical islet transplantation trials for the treatment of type 1 diabetes. The purpose of this study was to investigate whether exenatide has anti-inflammatory properties in human islets… CONTINUE READING


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