Anti-inflammatory properties of a platelet-activating factor acetylhydrolase

@article{Tjoelker1995AntiinflammatoryPO,
  title={Anti-inflammatory properties of a platelet-activating factor acetylhydrolase},
  author={Larry W. Tjoelker and Cheryl L. Wilder and Christine Eberhardt and Diana M. Stafforinit and Gregory N. Dietsch and Brian A. Schimpf and Shawnee Hooper and Hai Le Trong and Lawrence S. Cousens and Guy A Zimmerman and Yoshiji Yamadat and Thomas M. Mclntyre and Stephen M. Prescott and Patrick W. Gray},
  journal={Nature},
  year={1995},
  volume={374},
  pages={549-553}
}
PLATELET-ACTIVATING factor (PAF) is a potent pro-inflammatory phospholipid that activates cells involved in inflammation1,2. The biological activity of PAF depends on its structural features, namely an ether linkage at the sn-1 position and an acetate group at the sn-2 position. The actions of PAF are abolished by hydrolysis of the acetyl residue, a reaction catalysed by PAF acetylhydrolase. There are at least two forms of this enzyme-one intracellular and another that circulates in plasma and… 

Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase.

This review will focus on the potential of PAF-AH as a modulator of diseases of dysregulated inflammation, namely the intracellular types I and II and a plasma type.

The structure and function of platelet-activating factor acetylhydrolases

Abstract. Platelet-activating factor acetylhydrolases (PAF-AHs, EC 3.1.1.47) constitute a unique and biologically important family of phospholipase A2s. They are related to neither the

Platelet-activating Factor Acetylhydrolases*

The nature of the substrates hydrolyzed by PAF acetylhydrolases points at key roles for these activities in physiology and pathology, and it has provided important clues into what is currently thought to be the main function of these enzymes, which is to act as scavengers of bioactive phospholipids.

Roles of plasma platelet-activating factor acetylhydrolase in allergic, inflammatory, and atherosclerotic diseases.

Insight is provided into the functions of PAF and oxidized phospholipids as well as into the etiology of allergic, inflammatory, and atherosclerotic diseases.

To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase

This review seeks to address concerns around the functional role of the plasma form of platelet-activating factor acetylhydrolase, and addresses concerns of structurally related multiple ligands for PAF-R with varied potency and continuous PAF production by the so called bi-cycle of PAF makes PAF more enigmatic.

Crystal Structure of Human Plasma Platelet-activating Factor Acetylhydrolase

The model of interface binding begins to explain the known specificity of lipoprotein-bound substrates and how the active site can be both close to the hydrophobic-hydrophilic interface and at the same time be accessible to the aqueous phase.

Identification of platelet-activating factor acetylhydrolase II in human skin.

Overexpression of platelet-activating factor acetylhydrolase II protected HaCaT cells against apop tosis induced by oxidative stressors t-butylhydroperoxide and ultraviolet B radiation, and evidence that this specialized phospholipase is involved in protecting this organ against oxidative stress through the degradation of oxidatively modified bioactive phospholIPids is provided.

Biology of Platelet-activating Factor Acetylhydrolase (PAF-AH, Lipoprotein Associated Phospholipase A2)

Current knowledge related to the structural features of PAF-AH are discussed, including the molecular basis for association with lipoproteins and susceptibility to oxidative inactivation, which suggests that increased expression of this enzyme is a physiological response to inflammatory stimuli.
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