Anti-inflammatory properties of CB1-receptor antagonist involves beta2 adrenoceptors.

  title={Anti-inflammatory properties of CB1-receptor antagonist involves beta2 adrenoceptors.},
  author={Stephen J Mnich and Ronald R Hiebsch and Rita M. Huff and Shanmugam Muthian},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={333 2},
Antagonists of the cannabinoid receptor 1 (CB1) impart anti-inflammatory activity even though, paradoxically, CB2 receptors are more predominant on cells of the immune system. We attempted to understand the mechanism of this activity by using an acute model of lipopolysaccharide-induced inflammation/stress in both rat and mouse, with selective antagonists to CB1 receptors. We demonstrate that the ability of a CB1 antagonist to inhibit release of proinflammatory cytokines is not dependent on… CONTINUE READING
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