Anti-inflammatory pharmacotherapy during pregnancy

@article{stensen2004AntiinflammatoryPD,
  title={Anti-inflammatory pharmacotherapy during pregnancy},
  author={Monika {\O}stensen and Johan Fredrik Skomsvoll},
  journal={Expert Opinion on Pharmacotherapy},
  year={2004},
  volume={5},
  pages={571 - 580}
}
NSAIDs or cyclooxygenase inhibitors (COX inhibitors), including aspirin, are widely used to treat pain, fever and the articular symptoms of chronic rheumatic diseases. Manifestations of connective tissue or autoimmune diseases are commonly treated with glucocorticosteroids. The effect and side effects of NSAIDs depend on the isoforms of cyclooxygenases that they preferentially or selectively inhibit. The use of COX inhibitors has recently been associated with infertility and miscarriage. The… 
Nonsteroidal Anti-Inflammatory Drugs During Pregnancy and the Initiation of Lactation
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In the third trimester, NSAIDs and aspirin are usually avoided because of significant fetal risks such as renal injury, oligohydramnios, constriction of the ductus arteriosus (with potential for persistent pulmonary hypertension in the newborn), necrotizing enterocolitis, and intracranial hemorrhage.
Selective cyclooxygenase-2 inhibitors in dentistry: limitations and adverse effects
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The coxibs should be used in patients over 60 years, with a history of peptic ulcer or gastrointestinal bleeding, chronic users of corticosteroids and anticoagulants without concomitant cardiovascular risk, and in dentistry, where there is no major evidence of the benefits of using these drugs compared to traditional NSAIDs.
Use of non-steroidal anti-inflammatory drugs in pregnancy: impact on the fetus and newborn.
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The placental transfer and metabolism of NSAIDs, and the adverse impact of prenatal NSAID exposure on the offspring are discussed in detail.
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TLDR
The present study reviews the information currently available on NSAIDs, with special emphasis on those aspects related to dental practice, and discusses paracetamol and ibuprofen, the most widely used NSAIDs.
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Evidence is provided that shows the involvement of PGs in immunosuppression and secondary anemia, as well as the efficacy of inhibited overproduction ofPGs in many pathologic conditions other than rheumatologic disease.
Antirheumatic medications in pregnancy and breastfeeding.
TLDR
Because many patients are hesitant to use antirheumatic medications during pregnancy, honest and accurate discussions about pregnancy planning and management are important to help women make decisions that are in their and their offspring's best interest.
Safety and Efficacy of Non-prescription, Over-the-Counter (OTC) Ibuprofen
TLDR
The relative safety and efficacy of ibuprofen requires consideration in special groups such as the elderly, young and during pregnancy and lactation, and the frequently accepted view that safety at OTC doses in normal adults may be extended to being similar in these special groups may be generally applicable.
Selecting Nonprescription Analgesics
  • G. Peterson
  • Medicine
    American journal of therapeutics
  • 2005
TLDR
Despite the possibility of hepatotoxicity in overdose, paracetamol represents a better all-round option for most patients requiring OTC analgesic therapy, and is the simple analgesic drug of first choice.
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