Anti-inflammatory pharmacotherapy during pregnancy

@article{stensen2004AntiinflammatoryPD,
  title={Anti-inflammatory pharmacotherapy during pregnancy},
  author={M. {\O}stensen and J. Skomsvoll},
  journal={Expert Opinion on Pharmacotherapy},
  year={2004},
  volume={5},
  pages={571 - 580}
}
NSAIDs or cyclooxygenase inhibitors (COX inhibitors), including aspirin, are widely used to treat pain, fever and the articular symptoms of chronic rheumatic diseases. Manifestations of connective tissue or autoimmune diseases are commonly treated with glucocorticosteroids. The effect and side effects of NSAIDs depend on the isoforms of cyclooxygenases that they preferentially or selectively inhibit. The use of COX inhibitors has recently been associated with infertility and miscarriage. The… Expand
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  • Medicine
  • American journal of therapeutics
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References

SHOWING 1-10 OF 115 REFERENCES
Non-steroidal anti-inflammatory drugs as a possible cause for reversible infertility.
TLDR
NSAIDs, used largely for the treatment of rheumatological conditions, may be responsible for some cases of infertility, as reported in four women suffering from severe arthritis, on long-term NSAIDs and undergoing extensive investigation and treatment for infertility. Expand
Analysis of the nonsteroidal anti-inflammatory drug literature for potential developmental toxicity in rats and rabbits.
TLDR
A comprehensive analysis of the non-clinical NSAID literature demonstrated a possible association between exposure to NSAIDs and developmental anomalies, and these anomalies were similar for aspirin and for other NSAIDs, but effects occurred at a much lower incidence with non-aspirin NSAIDs than previously reported with aspirin. Expand
Teratogen update: fetal effects of indomethacin administration during pregnancy.
Indomethacin is a nonsteroidal anti-inflammatory analgesic used in the treatment of disorders such as rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. Prostaglandins have aExpand
Nonsteroidal antiinflammatory drugs and reproduction.
  • M. Dawood
  • Medicine
  • American journal of obstetrics and gynecology
  • 1993
TLDR
Pstaglandin inhibition with some nonsteroidal antiinflammatory drugs appear promising in the relief of some premenstrual symptoms and in the prevention of postoperative pelvic adhesion formation, but more studies are needed in women. Expand
[Neonatal chronic kidney failure associated with cyclo-oxygenase-2 inhibitors administered during pregnancy].
TLDR
The occurrence of chronic renal failure in strict relationship with maternal nimesulide assumption in this case is strongly suggestive for a pharmacological damage, either direct or mediated by renin angiotensin inhibition, and likely to account for the different outcome of similarly treated patients. Expand
Variants of cyclooxygenase-1 and their roles in medicine.
  • D. Simmons
  • Chemistry, Medicine
  • Thrombosis research
  • 2003
TLDR
COX-3, a variant of COX-1, has been found in canine brain and is inhibited by acetaminophen and dipyrone at physiological concentrations, which suggests the presence of cell-specific differences that govern COX inhibition by these drugs. Expand
COX-1 and COX-3 inhibitors.
TLDR
It is possible that inhibition of cyclooxygenase (COX)-1 is the major action of aspirin involved in its analgesic and antipyretic effects, and inhibition of COX-2 is responsible for its anti-inflammatory action. Expand
Cyclooxygenase‐independent actions of cyclooxygenase inhibitors
TLDR
Differences in cyclooxygenase‐independent mechanisms may have consequences for the specific use of these drugs in individual patients because additional effects may either enhance the efficacy or reduce the toxicity of the respective compounds. Expand
Cyclooxygenase inhibitors--current status and future prospects.
TLDR
Agents that inhibit COX-2 while sparing COx-1 represent a new attractive therapeutic development and could represent a major advance in the treatment of rheumatoid arthritis and osteoarthritis. Expand
Drugs in pregnancy. Rheumatological disorders.
  • M. Østensen
  • Medicine
  • Best practice & research. Clinical obstetrics & gynaecology
  • 2001
TLDR
Data on the use of antirheumatic drugs during pregnancy is presented, addressing the risk of teratogenicity, possible long-term effects on the infant exposed to drugs antenatally, and maternal side-effects which interfere with pregnancy. Expand
...
1
2
3
4
5
...