Anti-inflammatory mechanism of ginseng saponins in activated microglia

@article{Park2009AntiinflammatoryMO,
  title={Anti-inflammatory mechanism of ginseng saponins in activated microglia},
  author={Jin-Sun Park and Eun-mi Park and Dong-Hyun Kim and Kangsik Jung and Hee-Sun Kim},
  journal={Journal of Neuroimmunology},
  year={2009},
  volume={209},
  pages={40-49}
}
In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-kappaB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the… CONTINUE READING

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Anti-inflammatory mechanisms of isoflavone metabolites in lipopolysaccharide-stimulated microglial cells.

The Journal of pharmacology and experimental therapeutics • 2007
View 1 Excerpt

Atlas of Alzheimer's disease

H. H. Feldman
Informa, UK, • 2007
View 3 Excerpts

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