Anti-inflammatory mechanism of ginseng saponins in activated microglia

  title={Anti-inflammatory mechanism of ginseng saponins in activated microglia},
  author={Jin-Sun Park and Eun-mi Park and Dong-Hyun Kim and Kangsik Jung and Hee-Sun Kim},
  journal={Journal of Neuroimmunology},
In the present study, we investigated the effect of ginseng extract (KRG) and total saponins (GTS) on microglial activation. KRG and GTS inhibited LPS-induced expression of iNOS, MMP-9 and proinflammatory cytokines in microglial cells. Suppression of microglial activation by ginseng was also observed in the mouse brain inflamed by LPS. Furthermore, KRG and GTS significantly suppressed NF-kappaB and MAP kinase activities, which are upstream signaling molecules in inflammation. Among the… CONTINUE READING

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