Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.

@article{Kim2007AntiinflammatoryLM,
  title={Anti-inflammatory lipid mediator 15d-PGJ2 inhibits translation through inactivation of eIF4A.},
  author={Woo Jae Kim and Joon Hyun Kim and S. K. Jang},
  journal={The EMBO journal},
  year={2007},
  volume={26 24},
  pages={5020-32}
}
The signaling lipid molecule 15-deoxy-delta 12,14-prostaglandin J2 (15d-PGJ2) has multiple cellular functions, including anti-inflammatory and antineoplastic activities. Here, we report that 15d-PGJ2 blocks translation through inactivation of translational initiation factor eIF4A. Binding of 15d-PGJ2 to eIF4A blocks the interaction between eIF4A and eIF4G that is essential for translation of many mRNAs. Cysteine 264 in eIF4A is the target site of 15d-PGJ2. The antineoplastic activity of 15d… CONTINUE READING

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