Anti-inflammatory evaluation of isoxazole derivatives

  title={Anti-inflammatory evaluation of isoxazole derivatives},
  author={Archana Kapoor},
A new series of isoxazole derivatives were synthesized by synthesizing various chalcone derivatives and cyclizing them to give resultant isoxazole derivatives (TPI1TPI20).. All the synthesized derivatives were characterized with FTIR and NMR spectral analysis and evaluated for their anti-inflammatory activity in vivo (carrageenan induced paw ooedema method in rats). The isoxazole derivatives TPI-7 and TPI-13 were found to be the most active compounds due to the presence of the methoxy group at… CONTINUE READING