Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.

  title={Anti-inflammatory endiandric acid analogues from the roots of Beilschmiedia tsangii.},
  author={Yun-Ting Huang and Hsun-Shuo Chang and G. Wang and M. Cheng and C. Chen and Yi-Jen Yang and I. Chen},
  journal={Journal of natural products},
  volume={74 9},
  • Yun-Ting Huang, Hsun-Shuo Chang, +4 authors I. Chen
  • Published 2011
  • Chemistry, Medicine
  • Journal of natural products
  • Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1-8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC(50… CONTINUE READING
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