Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells.

  title={Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells.},
  author={Navdeep Chehl and Galina Chipitsyna and Qiaoke Gong and Charles J Yeo and Hwyda A Arafat},
  journal={HPB : the official journal of the International Hepato Pancreato Biliary Association},
  volume={11 5},
BACKGROUND Both hereditary and sporadic forms of chronic pancreatitis are associated with an increased risk of developing pancreatic ductal adenocarcinoma (PDA). Inflammation has been identified as a significant factor in the development of solid tumour malignancies. We have recently shown that thymoquinone (Tq), the major constituent of Nigella sativa oil extract, induced apoptosis and inhibited proliferation in PDA cells. Tq also increased p21 WAF1 expression, inhibited histone deacetylase… CONTINUE READING


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