Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways.

@article{Gao2012AntiinflammatoryEO,
  title={Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-$\kappa$B and MAPKs signaling pathways.},
  author={Yonglin Gao and Wang-lin Jiang and Chaohua Dong and Chunmei Li and Xuejun Fu and Li Min and J. Tian and Haizhu Jin and Jingyu Shen},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2012},
  volume={26 1},
  pages={
          1-6
        }
}
Sophocarpine, a tetracyclic quinolizidine alkaloid, is one of the most abundant active ingredients in Sophora alopecuroides L. Our previous studies have showed that sophocarpine exerts anti-inflammatory activity in animal models. In the present study, anti-inflammatory mechanisms of sophocarpine were investigated in lipopolysaccharide (LPS)-induced responses in RAW 264.7 cells. Furthermore, the cytotoxicity of sophocarpine was tested. The results indicated that sophocarpine could increase the… Expand
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