Anti-inflammatory effects of moxifloxacin and human beta-defensin 2 association in human lung epithelial cell line (A549) stimulated with lipopolysaccharide.

@article{Donnarumma2007AntiinflammatoryEO,
  title={Anti-inflammatory effects of moxifloxacin and human beta-defensin 2 association in human lung epithelial cell line (A549) stimulated with lipopolysaccharide.},
  author={Giovanna Donnarumma and Iole Paoletti and Elisabetta Buommino and Maria Rosaria Iovene and Laura Tudisco and Valentina Cozza and Maria Antonietta Tufano},
  journal={Peptides},
  year={2007},
  volume={28 12},
  pages={2286-92}
}
Epithelia in the human airways, from the nasal aperture to the alveoli, are covered in a protective film of fluid containing a number of antimicrobial proteins. Defensins are single-chain, strongly cationic peptides and are one of the most extensively studied classes of antimicrobial peptides. Moxifloxacin (MXF) is a fluoroquinolone that acts against both Gram positive and Gram negative bacteria. In this study, we evaluated the effects of HBD2, MXF and the association MXF/HBD2 on some cytokines… CONTINUE READING

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