Anti-inflammatory effects of leptin and cholecystokinin on acetic acid-induced colitis in rats: role of capsaicin-sensitive vagal afferent fibers

  title={Anti-inflammatory effects of leptin and cholecystokinin on acetic acid-induced colitis in rats: role of capsaicin-sensitive vagal afferent fibers},
  author={Ayhan Bozkurt and Barış Çakır and Feriha Ercan and Berrak Ç. Yeğen},
  journal={Regulatory Peptides},

Cholecystokinin/Cholecystokinin-1 Receptor-Mediated Peripheral Activation of the Afferent Vagus by Enteral Nutrients Attenuates Inflammation in Rats

A novel gut-brain-immune axis is revealed and the applicability of enteral nutrition to treat inflammatory conditions is provided, demonstrating that enteral lipid-rich nutrition modulates inflammation and preserves intestinal integrity via CCK release which activates CCK-1 receptors located on afferent vagal fibers.

Leptin inhibits gastric emptying in rats: role of CCK receptors and vagal afferent fibers.

The results indicate the existence of a functional interaction between leptin and CCK receptors leading to inhibition of gastric emptying and short-term suppression of food intake, providing an additional feedback control in producing satiety.

Chylomicron formation and glucagon-like peptide 1 receptor are involved in activation of the nutritional anti-inflammatory pathway.

Involvement of MAPK/NF-κB Signaling in the Activation of the Cholinergic Anti-Inflammatory Pathway in Experimental Colitis by Chronic Vagus Nerve Stimulation

Vagal activity modification contributes to the beneficial effects of the cholinergic anti-inflammatory pathway in IBD-related inflamed colonic mucosa based on the activation of MAPKs and nuclear translocation of NF-κB.

Cholecystokinin Modulates the Mucosal Inflammatory Response and Prevents the Lipopolysaccharide-Induced Intestinal Epithelial Barrier Dysfunction.

It is demonstrated that CCK preserves the integrity of the intestinal mucosa and might be a promising hormonal adjuvant therapy for the treatment of sepsis.

Elevated expression of the leptin receptor ob‑R may contribute to inflammation in patients with ulcerative colitis.

Activation of the leptin receptor ob‑R is an important pathogenic mechanism of UC, and leptin receptor deficiency may provide resistance against TNBS‑induced colitis by inhibiting the NF‑κB and RhoA signaling pathways.

Effect of Fish or Soybean Oil-Rich Diets on Bradykinin, Kallikrein, Nitric Oxide, Leptin, Corticosterone and Macrophages in Carrageenan Stimulated Rats

Data show that both fish and soybean oil-rich diets promote similar alterations on inflammatory mediators of carrageenan edema and a causal association with the anti-inflammatory effect of these diets.



Brain-gut axis in gastroprotection by leptin and cholecystokinin against ischemia-reperfusion induced gastric lesions.

  • T. BrzozowskiP. Konturek E. Hahn
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2001
Central leptin exerts a potent gastroprotective activity against I/R-induced gastric erosions that progress into deeper gastric lesions and this protection depends upon vagal activity and sensory nerves and involves hyperemia probably mediated by NO.

Central Leptin and Cholecystokinin in Gastroprotection against Ethanol-Induced Damage

Central leptin exerts a potent gastroprotective action at a dose that has no influence on gastric secretion and this protection depends upon CCKB receptors, vagal activity and sensory nerves, and involves hyperemia.

Cholecystokinin is a potent protective agent against alcohol-induced gastric injury in the rat

Cholecystokinin is able to maintain mucosal integrity in the face of a damaging insult by activation of type A cholecystokerin receptors, an effect mediated, at least in part, through the release of endogenous prostaglandins.

Gastroprotection and control of food intake by leptin. Comparison with cholecystokinin and prostaglandins.

Exogenous leptin and CCK, causing similar increments in plasma immunoreactive leptin levels, protect dose-dependently gastric mucosa against the damage provoked by 75% ethanol, suggesting that the protection afforded by these substances are mediated, at least in part, by gastric hyperemia.

Role of leptin in ulcer healing.

Protection induced by cholecystokinin‐8 (CCK‐8) in ethanol‐induced gastric lesions is mediated via vagal capsaicin‐sensitive fibres and CCKA receptors

The results demonstrate that the mucosal protective effect of CCK‐8 involves, at least in part, the activation of CCKA‐receptors and is mediated by vagal capsaicin‐sensitive fibres.