Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia.

@article{Jeong2014AntiinflammatoryEO,
  title={Anti-inflammatory effects of genistein via suppression of the toll-like receptor 4-mediated signaling pathway in lipopolysaccharide-stimulated BV2 microglia.},
  author={Jin-Woo Jeong and Hye Hyeon Lee and Min Ho Han and Gi-young Kim and Wun Jae Kim and Young Hyun Choi},
  journal={Chemico-biological interactions},
  year={2014},
  volume={212},
  pages={30-9}
}
Genistein, a principal soy isoflavone, has received considerable attention as a protein kinase inhibitor. Although some studies have demonstrated that genistein possesses anti-inflammatory effects, the molecular mechanisms of genistein-mediated anti-inflammatory potential are unclear in microglial cells. In this study, we determined whether genistein attenuates pro-inflammatory responses in lipopolysaccharide (LPS)-stimulated BV2 microglia and attempted to establish the possible mechanisms. Our… CONTINUE READING

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