Anti-inflammatory effects of aspirin and sodium salicylate.

  title={Anti-inflammatory effects of aspirin and sodium salicylate.},
  author={Rainer Amann and Bernhard A. Peskar},
  journal={European journal of pharmacology},
  volume={447 1},
Aspirin (acetylsalicylic acid) is one of the most widely used drugs worldwide. It acetylates cyclooxygenases thereby irreversibly blocking the conversion of arachidonic acid to prostanoids. Biotransformation of aspirin yields salicylate, a compound that possesses similar anti-inflammatory potency as aspirin but lacks aspirin's inhibitory effect on the activity of isolated cyclooxygenase. This article is aimed at providing an overview about the often conflicting results concerning the mechanisms… CONTINUE READING


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