Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke.

  title={Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke.},
  author={Robert W. Regenhardt and Fiona Desland and Adam P. Mecca and David J. Pioquinto and Aqeela Afzal and J D Mocco and Colin Sumners},
Previously we demonstrated that central administration of angiotensin-(1-7) [Ang-(1-7)] into rats elicits significant cerebroprotection against ischemic stroke elicited by endothelin-1 induced middle cerebral artery occlusion. Ang-(1-7), acting via its receptor Mas, reduced cerebral infarct size, and rats exhibited improved performance on neurological exams. These beneficial actions of Ang-(1-7) were not due to inhibition of the effects of endothelin-1 on cerebral vasoconstriction or effects on… CONTINUE READING
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