Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke

@article{Regenhardt2013AntiinflammatoryEO,
  title={Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke},
  author={Robert W. Regenhardt and F. Desland and A. P. Mecca and David J. Pioquinto and C. Sumners},
  journal={Neuropharmacology},
  year={2013},
  volume={71},
  pages={154-163}
}
  • Robert W. Regenhardt, F. Desland, +2 authors C. Sumners
  • Published 2013
  • Biology, Medicine
  • Neuropharmacology
  • Previously we demonstrated that central administration of angiotensin-(1-7) [Ang-(1-7)] into rats elicits significant cerebroprotection against ischemic stroke elicited by endothelin-1 induced middle cerebral artery occlusion. Ang-(1-7), acting via its receptor Mas, reduced cerebral infarct size, and rats exhibited improved performance on neurological exams. These beneficial actions of Ang-(1-7) were not due to inhibition of the effects of endothelin-1 on cerebral vasoconstriction or effects on… CONTINUE READING
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