Anti-inflammatory effects of DX-890, a human neutrophil elastase inhibitor.

BACKGROUND Neutrophil elastase (NE)-mediated inflammation contributes to lung damage in cystic fibrosis (CF). We investigated if DX-890, a small-protein NE inhibitor, could reduce neutrophil trans-epithelial migration and reduce activity released from neutrophils and NE-induced cytokine expression in airway epithelial cells. METHODS Activated blood… CONTINUE READING