Anti-inflammatory effects of 4'-demethylnobiletin, a major metabolite of nobiletin.

  title={Anti-inflammatory effects of 4'-demethylnobiletin, a major metabolite of nobiletin.},
  author={Xian Wu and Mingyue Song and Kanyasiri Rakariyatham and Jinkai Zheng and Shan-Shan Guo and Zhonghai Tang and Shuangde Zhou and H. G. Xiao},
  journal={Journal of functional foods},
  volume={19 Pt A},
Nobiletin, a citrus flavonoid has been associated with various beneficial biological activities. 4'-Demethylnobiletin (4DN) is a major metabolite of nobiletin and its tissue level was found to be much higher than that of nobiletin after oral administration of nobiletin in mice. Anti-inflammatory effects of 4DN were studied in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. The results showed 4DN not only dose-dependently inhibited LPS-induced nitric oxide production, but also… CONTINUE READING