Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.

@article{Sulaiman2010AntiinflammatoryEO,
  title={Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice.},
  author={M. Sulaiman and E. K. Perimal and M. Akhtar and A. Mohamad and M. H. Khalid and N. A. Tasrip and F. Mokhtar and Z. Zakaria and N. Lajis and D. Israf},
  journal={Fitoterapia},
  year={2010},
  volume={81 7},
  pages={
          855-8
        }
}
The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed… Expand
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