Anti-inflammatory effect of sargachromanol G isolated from Sargassum siliquastrum in RAW 264.7 cells

  title={Anti-inflammatory effect of sargachromanol G isolated from Sargassum siliquastrum in RAW 264.7 cells},
  author={Weon Jong Yoon and Soo-jin Heo and Sang-chul Han and Hye Ja Lee and Gyeoung Jin Kang and Hee-kyoung Kang and Jin Won Hyun and Young Sang Koh and Eun Sook Yoo},
  journal={Archives of Pharmacal Research},
  • W. Yoon, S. Heo, E. Yoo
  • Published 1 September 2012
  • Biology, Chemistry
  • Archives of Pharmacal Research
A study on the anti-inflammatory activity of brown alga Sargassum siliquastrum led to the isolation of sargachromanol G (SG). In this study, the anti-inflammatory effect and the action mechanism of SG have been investigated in murine macrophage cell line RAW 264.7. SG dosedependently inhibited the production of inflammatory markers [nitric oxide (NO), inducible nitric oxide synthase (iNOS), prostaglandin E2 (PGE2), and cyclooxygenase-2 (COX-2)] and pro-inflammatory cytokines [tumor necrosis… 

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