Anti-inflammatory effect of recombinant human superoxide dismutase in rats and mice and its mechanism.

@article{Zhang2002AntiinflammatoryEO,
  title={Anti-inflammatory effect of recombinant human superoxide dismutase in rats and mice and its mechanism.},
  author={Yi Zhang and Jun-Zhi Wang and Yong-jie Wu and Wen-guang Li},
  journal={Acta pharmacologica Sinica},
  year={2002},
  volume={23 5},
  pages={439-44}
}
AIM To investigate the anti-inflammatory effects and mechanism of recombinant human superoxide dismutase (rhSOD). METHODS Inflammation models such as croton oil-induced ear swelling and carrageenan-induced hind paw edema in mice and rats were prepared. The nitric oxide synthase (NOS ) activity was measured by NADPH-diaphoras stain assay, N-acetyl-beta-D-glucosaminidase (beta-NAG) activity by spectrophotography, malondialdehyde (MDA) content by thiobarbituric acid (TBA) fluorescence technique… CONTINUE READING

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