Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells.

@article{Yoo2000AntiinflammatoryEO,
  title={Anti-inflammatory effect of heat shock protein induction is related to stabilization of I kappa B alpha through preventing I kappa B kinase activation in respiratory epithelial cells.},
  author={C. G. Yoo and Sun Kyung Lee and Choon Taek Lee and Young Whan Kim and Sung Koo Han and Young Soo Shim},
  journal={Journal of immunology},
  year={2000},
  volume={164 10},
  pages={5416-23}
}
Heat shock protein (HSP) induction confers protection against diverse forms of cellular and tissue injury. However, the mechanism by which HSP exerts cytoprotective effects is unclear. Because HSP induction inhibits genetic expression of pro-inflammatory cytokines, the transcription of which is dependent on NF-kappa B activation, we explored the relationship between the anti-inflammatory effect of HSP induction and the NF-kappa B/I kappa B alpha pathway. Both HS and sodium arsenite treatment… CONTINUE READING

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