Corpus ID: 44220857

Anti-inflammatory effect of flavonoids from Comfort-G and the changes in arachidonic acid metabolism

  title={Anti-inflammatory effect of flavonoids from Comfort-G and the changes in arachidonic acid metabolism},
  author={Marek Vecka and Lubom{\'i}r Proke{\vs} and Eva Tvrzicka and A. Pernicky and Raymond C. Pfleger},
SUMMARY Objective: Flavonoids from preparation Comfort-G have, beside of antioxidant effects, the anti-inflammatory effect, too. Comfort-G inhibits both COX-1 (cyclooxygenase-1)/COX-2 (cyclooxygenase-2) and 5-LO (5-lipoxygenase) enzymatic activity thereby decreasing the transformation of arachidonic acid (AA) to prostaglandins, thromboxanes, and leukotrienes. Our goal was to confirm this finding by the analysis of the content of AA in synovial fluid and serum of patients suffering by… Expand
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