Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice

@article{Melo2011AntiinflammatoryEO,
  title={Anti-inflammatory effect of α,β-amyrin, a triterpene from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice},
  author={Caroline M. Melo and Talita Cavalcante Morais and Adriana da Rocha Tom{\'e} and Gerly Anne de Castro Brito and Mariana Helena Chaves and Vietla Satyanarayana Rao and Fl{\'a}via Santos},
  journal={Inflammation Research},
  year={2011},
  volume={60},
  pages={673-681}
}
To evaluate the anti-inflammatory effect of α,β-amyrin, a pentacyclic triterpenoid from Protium heptaphyllum, on cerulein-induced acute pancreatitis in mice. Acute pancreatitis was induced in Swiss mice by five intraperitoneal injections of cerulein (50 μg/kg), at 1 h intervals. Mice received α,β-amyrin (10, 30 and 100 mg/kg), thalidomide (200 mg/kg), or vehicle (3% Tween 80) orally 1 h before and 12 h after the cerulein challenge. The severity of pancreatitis was evaluated 24 h after cerulein… CONTINUE READING