Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro.

@article{Goehring2017AntiinflammatoryDD,
  title={Anti-inflammatory drugs decrease infection of brain endothelial cells with EHV-1 in vitro.},
  author={Lutz S Goehring and Kite Brandes and Laura V. Ashton and Luke A. Wittenburg and Francisco J. Olea-Popelka and David P. Lunn and Gisela Soboll Hussey},
  journal={Equine veterinary journal},
  year={2017},
  volume={49 5},
  pages={629-636}
}
BACKGROUND Equine herpesvirus-associated myeloencephalopathy is the result of endothelial cell infection of the spinal cord vasculature with equine herpesvirus-1 (EHV-1) during cell-associated viraemia. Endothelial cell infection requires contact between infected peripheral blood mononuclear and endothelial cells. Inflammation generated during viraemia likely upregulates adhesion molecule expression on both cell types increasing contact and facilitating endothelial cell infection. OBJECTIVES… CONTINUE READING