Anti-inflammatory drugs block cytokine mRNA accumulation in the skin and improve the clinical condition of reactional leprosy patients.

@article{Moraes2000AntiinflammatoryDB,
  title={Anti-inflammatory drugs block cytokine mRNA accumulation in the skin and improve the clinical condition of reactional leprosy patients.},
  author={Milton Oz{\'o}rio Moraes and Euzenir Nunes Sarno and Rosane Magda Brand{\~a}o Teles and Alexandre S. Almeida and B C Saraiva and Jos{\'e} Augusto da Costa Nery and Elizabeth Pereira Sampaio},
  journal={The Journal of investigative dermatology},
  year={2000},
  volume={115 6},
  pages={
          935-41
        }
}
The aim of this study was to investigate in what ways in vivo anti-inflammatory treatment affects cytokine mRNA expression in situ in both erythema nodosum leprosum and reversal reaction patients. Serial biopsies were collected from the patients undergoing leprosy reactions before and during pentoxifylline (n = 7) or thalidomide (n = 3) treatment for erythema nodosum leprosum and prednisone (n = 3) for reversal reaction. Clinical evolution of the skin lesion was assessed during the study and… CONTINUE READING
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