Anti-inflammatory drugs and their mechanism of action

@article{Vane1998AntiinflammatoryDA,
  title={Anti-inflammatory drugs and their mechanism of action},
  author={John R. Vane and R. M. Botting},
  journal={Inflammation Research},
  year={1998},
  volume={47},
  pages={78-87}
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) produce their therapeutic activities through inhibition of cyclooxygenase (COX), the enzyme that makes prostaglandins (PGs). They share, to a greater or lesser degree, the same side effects, including gastric and renal toxicity. Recent research has shown that there are at least two COX isoenzymes. COX-1 is constitutive and makes PGs that protect the stomach and kidney from damage. COX-2 is induced by inflammatory stimuli, such as cytokines, and… CONTINUE READING
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Referenced Papers

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New highly selective COX-2 inhibitors

  • AW Ford-Hutchinson
  • 1998
1 Excerpt

Specific COX-2 inhibitors: From bench to bedside

  • P Isakson, B Zweifel, J Masferrer, C Koboldt, K Seibert, R Hubbard
  • 1998
2 Excerpts

A pilot endoscopic study of the gastroduodenal effects of SC-58635, a novel COX-2 selective inhibitor [abstract]. Gastroenterology 1997;112:A194

  • FL Lanza, MF Rack, DA Callison, RC Hubbard, SS Yu, S Talwalker
  • 1997
1 Excerpt

A pilot endoscopic study of the gastroduodenal effects of SC58635 , a novel COX - 2 selective inhibitor [ abstract ]

  • FL Lanza, MF Rack, DA Callison, RC Hubbard, SS Yu
  • Gastroenterology
  • 1997

Amyloid-b peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

  • SD Yan, H Zhu, J Fu, SF Yan, A Roher, WW Tourtellotte
  • Proc Natl Acad Sci USA
  • 1997
1 Excerpt

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