Anti-inflammatory drug evaluation in ApoE-/- mice by ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging.

@article{Sigovan2012AntiinflammatoryDE,
  title={Anti-inflammatory drug evaluation in ApoE-/- mice by ultrasmall superparamagnetic iron oxide-enhanced magnetic resonance imaging.},
  author={Monica Sigovan and Elena A Kaye and Eric Lancelot and Claire A Corot and Nicolas Provost and Zouher Majd and Magali Breisse and Emmanuelle Canet-Soulas},
  journal={Investigative radiology},
  year={2012},
  volume={47 9},
  pages={538-45}
}
OBJECTIVES The renin-angiotensin system and local phagocytic activity play a major role in atherosclerotic plaque development. Treatment with irbesartan, an antagonist of angiotensin II receptor, can decrease atherosclerotic lesion formation. Iron oxide-enhanced magnetic resonance imaging (MRI) can be successfully used to evaluate the phagocytic activity in the atherosclerotic plaque in mice. In this study, we used 2 iron oxide-enhanced MRI strategies, in vivo labeling by injection of iron… CONTINUE READING