Anti-inflammatory constituents from the fruits of Vitex rotundifolia.

@article{Lee2013AntiinflammatoryCF,
  title={Anti-inflammatory constituents from the fruits of Vitex rotundifolia.},
  author={Chul Ho Lee and Jin Woo Lee and Qinghao Jin and Hak Ju Lee and Sung-Joon Lee and Dongho Lee and Myung Koo Lee and Chong Kil Lee and Jin Tae Hong and Mi Kyeong Lee and Bang Yeon Hwang},
  journal={Bioorganic & medicinal chemistry letters},
  year={2013},
  volume={23 21},
  pages={6010-4}
}
Three new diterpenes (7, 15 and 17) and two new neolignans (19 and 20) along with nineteen known compounds have been isolated from the fruits of Vitex rotundifolia. Their structures were elucidated by a combination of 1D and 2D NMR, HRESI-MS, and CD data. All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells. Of these, compounds 3, 4, 7, 13, 15, 19, and 24 found to inhibit nitric oxide production with the IC50 values ranging from 11.3… CONTINUE READING

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