Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.

@article{Juliana2010AntiinflammatoryCP,
  title={Anti-inflammatory compounds parthenolide and Bay 11-7082 are direct inhibitors of the inflammasome.},
  author={Christine A Juliana and Teresa Fernandes-Alnemri and Jianghong Wu and Pinaki Datta and Leobaldo Solorzano and Je-Wook Yu and Rong Meng and Andrew A. Quong and Eicke Latz and Charles P. Scott and Emad S. Alnemri},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 13},
  pages={9792-802}
}
Activation of the inflammasome generates the pro-inflammatory cytokines interleukin-1 beta and -18, which are important mediators of inflammation. Abnormal activation of the inflammasome leads to many inflammatory diseases, including gout, silicosis, neurodegeneration, and genetically inherited periodic fever syndromes. Therefore, identification of small molecule inhibitors that target the inflammasome is an important step toward developing effective therapeutics for the treatment of… CONTINUE READING
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