Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors.

@article{Oger2004AntiinflammatoryAU,
  title={Anti-inflammatory and utero-relaxant effects in human myometrium of new generation phosphodiesterase 4 inhibitors.},
  author={St{\'e}phanie Oger and C{\'e}line M{\'e}hats and Mary S. Barnette and Françoise Ferr{\'e} and Dominique Cabrol and M. J. Leroy},
  journal={Biology of reproduction},
  year={2004},
  volume={70 2},
  pages={458-64}
}
The anti-inflammatory and utero-relaxant effects of two potent phosphodiesterase 4 (PDE4) inhibitors of the latest generation: cilomilast (one of the most advanced PDE4 inhibitors in clinical development, reportedly more selective for PDE4D) and compound A (which displays 12-fold greater selectivity toward PDE4B and/or PDE4A than toward PDE4D) were evaluated in human uterine smooth muscle. We first established that these compounds exhibit greater efficacy in inhibiting total cAMP-PDE activity… CONTINUE READING
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