Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.

  title={Anti-inflammatory and antioxidant activities of cat's claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content.},
  author={Manuel Sandoval and Nataly N. Okuhama and X J Zhang and L. A. Condezo and Juan Lao and Fausto M Angeles and Rabi Ann Musah and Paul J. Bobrowski and M J Miller},
  journal={Phytomedicine : international journal of phytotherapy and phytopharmacology},
  volume={9 4},
Cat's claw is an herbal medicine from the Amazon that is used widely to treat inflammatory disorders. The purpose of this study was to characterize the antioxidative and antiinflammatory properties of cat's claw, Uncaria tomentosa (UT) and Uncaria guianensis (UG). Alkaloids and flavanols were determined using reversed-phase HPLC; scavenging of 1,1-diphenyl-2-picrilhydrazyl (DPPH), hydroxyl radicals, and lipid peroxidation by spectrophotometry; and TNFalpha production by ELISA. Anti-inflammatory… 

Figures and Tables from this paper

Investigations on the anti-inflammatory and anti-allergic activities of the leaves of Uncaria guianensis (Aublet) J. F. Gmelin

Results demonstrate that U. guianensis leaves provide effective anti-inflammatory and anti-allergic activities.

Antioxidant Activity of an Aqueous Leaf Extract from Uncaria tomentosa and Its Major Alkaloids Mitraphylline and Isomitraphylline in Caenorhabditis elegans

The results suggest that the antioxidant activity of ALE in C. elegans is independent of its alkaloid content, and that SKN-1 is required for ALE-mediated stress resistance.

Association of various concentrations of cat's claw herb (Uncaria tomentosa) on lymphocyte proliferation and nitric oxide expression: An in-vitro study of osteoarthritis

The purpose of this study was to examine the association of cat’s claw at various dosages on lymphocyte proliferation and nitric oxide expression in osteoarthritis patients, which has implications for both the long-term safe use of the herb and valuable information for osteoartritis patients who may be currently using pharmaceutical prescriptions to manage the condition.

The protective role of extracts from leaves and bark of Uncaria tomentosa (Willd.) DC in oxidative damage of human erythrocytes provoked by 2,4-D herbicide

Ethanol-based extracts revealed more pronounced ability to inhibit oxidation processes in human erythrocytes, and protective effect of extracts of U. tomentosa was revealed.

The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in southern African

Some plant species used traditionally to treat pain have reasonable anti-inflammatory activity and flavonoids are probably not involved in this process.


Uncaria tomentosa , a climbing vine notable for containing high concentrations of oxindole alkaloids and phenolic compounds, is commonly used in traditional medicine as an anti-inflammatory and

The Effect of Rutin and Extracts of Uncaria guianensis (Aubl.) J. F. Gmeland on Primary Endometriotic Cells: A 2D and 3D Study

In vitro effects of rutin and the aqueous bark, roots, and leaf extracts and isolated components of Uncaria guianensis on stromal cells from eutopic endometrium and lesions of patients with endometriosis and applied treatments did not reduce cellular viability, but ROS production did increase.



Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection.

Efficacy and safety of freeze-dried cat's claw in osteoarthritis of the knee: mechanisms of action of the species Uncaria guianensis

Cat's claw is an effective treatment for osteoarthritis and their anti-inflammatory properties may result from their ability to inhibit TNFα and to a lesser extent PGE2 production.

Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng.

An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures.

Evaluation of the in vitro antioxidant activity in extracts of Uncaria tomentosa (Willd.) DC.

Different extracts of U. tomentosa were tested in vitro for their antioxidant activity utilizing tert ‐butyl‐hydroperoxide‐initiated chemiluminescence in rat liver homogenates, preventing TBARS production and free radical‐mediated DNA‐sugar damage.

Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado.

It is concluded that sangre de grado is a potent, cost-effective treatment for gastrointestinal ulcers and distress via antimicrobial, anti-inflammatory, and sensory afferent-dependent actions.

Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa.

Bioassay-directed fractionation of the anti-inflammatory extracts of Uncaria tomentosa, using the carrageenan-induced edema in rat paw, has led to the isolation of a new quinovic acid glycoside 7 as