Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum.

@article{Afzal2012AntiinflammatoryAA,
  title={Anti-inflammatory and analgesic potential of a novel steroidal derivative from Bryophyllum pinnatum.},
  author={Muhammad Afzal and Gaurav Gupta and Imran Kazmi and Mahfoozur Rahman and Obaid Afzal and Jahangir Md Alam and Khalidur Rahman Hakeem and Mohammad Pravez and Ritu Gupta and Firoz Anwar},
  journal={Fitoterapia},
  year={2012},
  volume={83 5},
  pages={853-8}
}
A new steroidal derivative, urs Stigmast-4, 20 (21), 23-trien-3-one and other four compounds were isolated from the leaves of Bryophyllum pinnatum. The structure of this new steroid was elucidated and established by standard spectroscopic methods. Carrageenan induced paw edema model was used for anti-inflammatory and acetic acid induced model used for analgesic activity. This new steroidal compound was found to be active in reducing inflammation (% inhibition 87.29 and 84.45 respectively) when… CONTINUE READING

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