Anti-inflammatory and analgesic effects of magnolol

@article{Wang1992AntiinflammatoryAA,
  title={Anti-inflammatory and analgesic effects of magnolol},
  author={Jih Pyang Wang and M F Hsu and Shue-Zing Raung and Chen-Chih Chen and J. -F. Kuo and C F Teng},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1992},
  volume={346},
  pages={707-712}
}
Magnolol, isolated from Magnolia officinalis, inhibited mouse hind-paw edema induced by carrageenan, compound 4880, polymyxin B and reversed passive Arthus reaction. Acetic acid-induced writhing response was depressed by magnolol, indomethacin and ibuprofen. The lethality of endotoxin challenge was reduced by pretreatment with magnolol, indomethacin and BW755C, a dual cyclo-oxygenase/lipoxygenase inhibitor. The recovered myeloperoxidase activity in edematous paw was significantly decreased in… CONTINUE READING