Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.

Abstract

A standardised 50% aqueous ethanolic extract of the Indian variety of Hypericum perforatum (IHp) was examined for its putative anti-inflammatory and analgesic activity at the doses of 100 and 200 mg/kg, po. The experimental paradigms used were carrageenan induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, whereas the tail flick, hot plate and acetic acid induced writhing methods were used to asses analgesic activity. Indomethacin (20 mg/kg, ip) was used as the standard anti-inflammatory drug. Pentazocine (10 mg/kg, ip) and aspirin (25 mg/kg, ip), both clinically used analgesics, were used as standard analgesics for comparison. IHp extract showed significant anti-inflammatory and analgesic activity at both dose levels, in all the paradigms used. Additionally, IHp potentiated the anti-inflammatory activity of indomethacin and analgesic activities of pentazocine and aspirin.

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Cite this paper

@article{Kumar2001AntiinflammatoryAA, title={Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.}, author={Vineet Kumar and Padam Singh and Sujit Bhattacharya}, journal={Indian journal of experimental biology}, year={2001}, volume={39 4}, pages={339-43} }