Anti-inflammatory and Hepatoprotective Effects of Quercetin in an Experimental Model of Rheumatoid Arthritis.

  title={Anti-inflammatory and Hepatoprotective Effects of Quercetin in an Experimental Model of Rheumatoid Arthritis.},
  author={Ana Carolina de Figueiredo Costa and Luane Macedo de Sousa and Joana Maria Dos Santos Alves and Paula Goes and Karuza Maria Alves Pereira and Ana Paula Negreiros Nunes Alves and Mariana Lima Vale and Delane Viana Gondim},
Rheumatoid arthritis (RA) is an autoimmune disease characterized by inflammation in the joints. Although methotrexate (MX) is the first-line treatment, side effects are common. This study aimed to investigate the effects of quercetin (QT) and/or MX on inflammation and systemic toxicity in a rat model of RA. Male Wistar rats were divided into control (C), RA, QT, MX, and QT + MX groups (n=6). The RA induction consisted of three intra-articular injections of methylated bovine serum albumin (1… 
3 Citations
Indigenous Nigeria medicinal herbal remedies: A potential source for therapeutic against rheumatoid arthritis.
The global burden of RA, the novel role of plant-based botanicals as potential therapeutics against signaling pathways in RA, and the possible repurposing/reprofiling of plantBotanicals to increase their therapeutic index among RA patients that patronize traditional healers in Nigeria are discussed.
Pharmacological Aspects of Natural Quercetin in Rheumatoid Arthritis
  • Mengshi Tang, Yan Zeng, Fen Li
  • Medicine
    Drug Design, Development and Therapy
  • 2022


Potent Inhibitory Effects of Quercetin on Inflammatory Responses of Collagen-Induced Arthritis in Mice.
Results suggest that oral administration of QUER might effectively improve symptoms of RA, and significantly decreases lipopolysaccharide (LPS)-induced TNF-α production in a dose-dependent manner.
Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis.
The Effect of Quercetin on Inflammatory Factors and Clinical Symptoms in Women with Rheumatoid Arthritis: A Double-Blind, Randomized Controlled Trial
Five hundred milligrams per day quercetin supplementation for 8 weeks resulted in significant improvements in clinical symptoms, disease activity, hs-TNFα, and HAQ in women with RA.
Quercetin ameliorates experimental autoimmune myocarditis in rats.
The present study suggests that quercetin ameliorates EAM, at least in part, by interfering production of proinflammatory (TNF-α and IL-17) and/or anti-inflammatory (IL-10) cytokines.
Quercetin promotes the apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1.
The findings of this study indicate that quercetin promotes RAFLS apoptosis by upregulating lncRNA MALAT1, and that MALAT1 induces apoptotic by inhibiting the activation of the PI3K/AKT pathway.
The advances of methotrexate resistance in rheumatoid arthritis
The recent findings regarding the critical signaling pathways of MTXR in RA are discussed, which provide research targets and directions for a drug therapy that develop preventive strategies and effective treatments ofMTXR.
IL-17 in Rheumatoid Arthritis and Precision Medicine: From Synovitis Expression to Circulating Bioactive Levels
New tools and concepts are required to identify patients that could benefit from these IL-17 targeted therapies in RA and the development of predictive biomarkers of response has started with the emergence of various bioassays.
The antioxidant effects of the flavonoids rutin and quercetin inhibit oxaliplatin-induced chronic painful peripheral neuropathy
Results suggest that nitric oxide and peroxynitrite are also involved in the neurotoxic effect of oxaliplatin and that rutin and quercetin can inhibit their effect in the spinal cord.
Methotrexate mechanism in treatment of rheumatoid arthritis.