Anti-inflammatory and Antioxidant Effects of Captopril Compared to Methylprednisolone in l-Arginine-Induced Acute Pancreatitis

  title={Anti-inflammatory and Antioxidant Effects of Captopril Compared to Methylprednisolone in l-Arginine-Induced Acute Pancreatitis},
  author={Nahla E. El‐Ashmawy and Naglaa F. Khedr and Hoda El-bahrawy and Omnia B. Hamada},
  journal={Digestive Diseases and Sciences},
BackgroundAcute pancreatitis (AP) is an inflammatory disease mediated by damage in acinar cells and pancreatic inflammation with infiltration of leukocytes. The pancreatic renin–angiotensin system may play an important role in the pathogenesis of AP.AimThe present study aimed to investigate the possible protective role of captopril (CAP), an angiotensin-converting enzyme inhibitor, in attenuating l-arginine-induced AP rat model and to elucidate the underlying molecular mechanisms.MethodsForty… 

Possible mechanisms mediating the protective effect of cilostazol in L-arginine induced acute pancreatitis in rats: role of cGMP, cAMP, and HO-1

It is suggested that cilostazol protects against L-arginine-induced AP, which may be related to an increase in cGMP, cAMP, and upregulation of HO-1 with subsequent anti-inflammatory and antioxidant properties.

Anti-Inflammatory Activities of Captopril and Diuretics on Macrophage Activity in Mouse Humoral Immune Response

Results showed that diuretics with or without captopril modulate the humoral response by affecting the function of macrophages, which has significant translational potential in assessing the safety of antihypertensive therapy.

Chymase as a Novel Therapeutic Target in Acute Pancreatitis

A chymase inhibitor may become a novel therapeutic agent for acute pancreatitis and be significantly reduced by treatment with TY-51469, according to the survival rate and biological markers evaluated.

Captopril suppresses hepatic mammalian target of rapamycin cell signaling and biomarkers of inflammation and oxidative stress in thioacetamide-induced hepatotoxicity in rats

Captopril protects against TAA-induced mTOR, liver injury enzymes, dyslipidemia, hypertension, inflammation, and oxidative stress, and demonstrated a significant positive correlation between mTOR scoring and the levels of inflammatory, oxidative and liver injury biomarkers.

Captopril Combined with Furosemide or Hydrochlorothiazide Affects Macrophage Functions in Mouse Contact Hypersensitivity Response

Diuretics administered alone or with captopril increase the generation of ROIs and reduce the formation of NO by macrophages, and tested drugs inhibit the secretion of IL-12.


MtEMD pretreatment results in a protective effect comparable with that of MP pretreatment in AP rat model, and shows dose dependent significant reduction in pancreatic nitrate and lipid peroxidation levels compared to disease group.

Modulating effect of luteolin on ethanol and cerulein induced inflammation— In silico and in vivo studies using rat model of pancreatitis

There was a strong binding affinity of luteolin towards procaspase-1, ASC-CARD,ASC-PYD that might interfere with the molecular assembly of NLRP3 inflammasome and the production of pro-inflammatory cytokines.

Tangeretin mitigates l-NAME-induced ventricular dysfunction and remodeling through the AT1R/pERK1/2/pJNK signaling pathway in rats.

Tangeretin exhibits antihypertensive effects and alleviates ventricular dysfunction and remodeling in hypertensive rats, associated with the inhibition of renin angiotensin system activation and restoration of pERK1/2, pJNK, and eNOS protein expressions along with reduced oxidative stress and increased NO bioavailability.



Modulation of L-arginine-induced acute pancreatitis by meloxicam and/or L-carnitine in rats

Treatment with both meloxicam and L-carnitine is a more effective than each of them alone which is attributed to augmentation their antioxidant, anti inflammatory effects.


Limonene has the potential to heal acute pancreatitis by acting as an antiinflammatory and antioxidant agent and historians findings confirmed the amelioration of pancreatic injury by limonene.

Antiapototic Effect of Captopril in Cisplatin-Induced Kidney Injury in Rats

Captopril protects against cisplatin nephrotoxicity by its antioxidant, anti-inflammatory and antiapoptotic potentials.

L-arginine-induced experimental acute pancreatitis

Different animal models of experimental acute pancreatitis induced by caerulein, choline deficient ethionine supplemented (CDE) diet, or sodium taurocholate have been developed. These models vary in

Histological study on the possible protective effect of pentoxifylline on pancreatic acini of l-arginine-induced acute pancreatitis in adult male albino rats

Pentoxifylline was found to improve the histological changes of pancreatic acini caused by l-arginine and showed amelioration of the histology picture, which was marked after daily pentoxifyLLine treatment for a week.

Protective effect of lawsone on L-Arginine induced acute pancreatitis in rats.

The histoimmunological findings further proved the amelioration of pancreatic injury by lawsone and further proved anti-inflammatory and antioxidant agent property of lawsone.

Therapeutic and Protective Effect of Wheat Germ Oil on L-arginine Induced Acute Pancreatitis in Adult Albino Rats

WGO has a therapeutic not a protective effect on L-arginine-induced AP which might be through its anti-inflammatory effects, but the acini showed significant improvement in the therapeutic group.

Captopril and telmisartan treatments attenuate cadmium‐induced testicular toxicity in rats

Immunohistochemical analysis revealed that both captopril and telmisartan significantly reduced the cadmium‐induced expression of inducible nitric oxide synthase, nuclear factor‐κB, Fas ligand, and caspase‐3 intesticular tissue, suggesting that both drugs equally protected the testicular tissue from the detrimental effects of Cadmium.

Alteration of the renin-angiotensin system in caerulein induced acute pancreatitis in the mouse.