Anti-inflammatory and Antioxidant Effects of Captopril Compared to Methylprednisolone in l-Arginine-Induced Acute Pancreatitis

@article{ElAshmawy2018AntiinflammatoryAA,
  title={Anti-inflammatory and Antioxidant Effects of Captopril Compared to Methylprednisolone in l-Arginine-Induced Acute Pancreatitis},
  author={Nahla E. El‐Ashmawy and Naglaa F. Khedr and Hoda El-bahrawy and Omnia B. Hamada},
  journal={Digestive Diseases and Sciences},
  year={2018},
  volume={63},
  pages={1497-1505}
}
BackgroundAcute pancreatitis (AP) is an inflammatory disease mediated by damage in acinar cells and pancreatic inflammation with infiltration of leukocytes. The pancreatic renin–angiotensin system may play an important role in the pathogenesis of AP.AimThe present study aimed to investigate the possible protective role of captopril (CAP), an angiotensin-converting enzyme inhibitor, in attenuating l-arginine-induced AP rat model and to elucidate the underlying molecular mechanisms.MethodsForty… 

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