Anti-inflammatory and Anti-apoptotic Effect of Combined Treatment with Methylprednisolone and Amniotic Membrane Mesenchymal Stem Cells After Spinal Cord Injury in Rats

@article{Gao2014AntiinflammatoryAA,
  title={Anti-inflammatory and Anti-apoptotic Effect of Combined Treatment with Methylprednisolone and Amniotic Membrane Mesenchymal Stem Cells After Spinal Cord Injury in Rats},
  author={Shan Gao and Jie Ding and Huimei Xiao and Zhi-qiang Li and Yan Chen and Xing-sheng Zhou and Jing-e Wang and Jiang Wu and Wei-Ze Shi},
  journal={Neurochemical Research},
  year={2014},
  volume={39},
  pages={1544-1552}
}
This study was undertaken to investigate the synergistic effects of methylprednisolone (MP) administration and transplantation of amniotic membrane mesenchymal stem cells (AM-MSCs) following T11 spinal cord clip compressive injury in rats. The combination treatment with MP (50 mg/kg) and delayed transplantation of AM-MSCs after rat spinal cord injury, significantly reduced (1) myeloperoxidase activity, (2) the proinflammatory cytokines: tumor necrosis factor-α, interleukin (IL)-1β, IL-6, IL-17… CONTINUE READING
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