Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).

@article{Aguilar2002AntiinflammatoryAO,
  title={Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).},
  author={J. Aguilar and P. Rojas and A. Marcelo and A. Plaza and R. Bauer and E. Reininger and C. Klaas and I. Merfort},
  journal={Journal of ethnopharmacology},
  year={2002},
  volume={81 2},
  pages={
          271-6
        }
}
We assessed in vivo the anti-inflammatory activity of two Cat's claw bark extracts, by comparing a spray-dried hydroalcoholic extract against an aqueous freeze-dried extract, to determine which extract was more effective. [...] Key Method We used the carrageenan-induced paw edema model in mice. In addition, to assess the molecular mechanism of action, we determined the inhibition of NF-kappa B through the Electrophoretic Mobility Shift Assay (EMSA) and the effects on cycloxygenase-1 and -2. Results showed that…Expand
Anti-inflammatory and antitumoural effects of Uncaria guianensis bark.
TLDR
Ug AIV was not cytotoxic for tumour cells or macrophages, and its anti-tumour effect may be due to a reduction in pro-Tumoural inflammatory processes in the tumour microenvironment, possibly mediated through NF-κB. Expand
Garden rue inhibits the arachidonic acid pathway, scavenges free radicals, and elevates FRAP: role in inflammation.
TLDR
The results demonstrated the anti-inflammatory and antioxidant activity of RG-M with potent inhibitory effects on the arachidonic acid pathways. Expand
Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark.
TLDR
Mitraphylline was tested in vivo against a large range of cytokines that play a crucial role in inflammation and did not show any toxicity on K565 cells nor murine macrophages at doses up to 100 μM. Expand
Immunostimulatory effects of Uncaria perrottetii (A. Rich.) Merr. (Rubiaceae) vinebark aqueous extract in Balb/C mice.
TLDR
Based on the results of both in vitro and in vivo trials, Uncaria perrottetii extract has immunopotentiating activities on the innate immunity of Balb/C mice and the extract could potentially reverse the immunosuppressive effects of Cy. Expand
Quinic acid is a biologically active component of the Uncaria tomentosa extract C-Med 100.
TLDR
It is reported that mice exposed to quinic acid (QA), a component of this extract, had significantly increased number of spleen cells, thus recapitulating the in vivo biological effect of C-Med 100 exposure. Expand
Investigations on the anti-inflammatory and anti-allergic activities of the leaves of Uncaria guianensis (Aublet) J. F. Gmelin
TLDR
Results demonstrate that U. guianensis leaves provide effective anti-inflammatory and anti-allergic activities. Expand
An ethanolic extract of Uncaria tomentosa reduces inflammation and B16- BL6 melanoma growth in C57BL/6 mice.
TLDR
UT did not show an important cytotoxic effect in vitro at the doses up to 300 μg/ml, but did inhibit tumor growth and metastasis in vivo, and inhibited TNF-α, IL-6 and NO production in vitro. Expand
Immunosuppressive effects of the standardized extract of Phyllanthus amarus on cellular immune responses in Wistar-Kyoto rats
TLDR
P. amarus showed effective immunosuppressive activities in cellular immune response, by various immune regulatory mechanisms, and may be useful for improvement of immune-related disorders. Expand
The Effect of Rutin and Extracts of Uncaria guianensis (Aubl.) J. F. Gmeland on Primary Endometriotic Cells: A 2D and 3D Study
TLDR
In vitro effects of rutin and the aqueous bark, roots, and leaf extracts and isolated components of Uncaria guianensis on stromal cells from eutopic endometrium and lesions of patients with endometriosis and applied treatments did not reduce cellular viability, but ROS production did increase. Expand
Experimental immunology The effect of the bark water extract Uncaria tomentosa on the Pseudomonas aeruginosa infection in mice
TLDR
After administration of Uncaria water extract a significantly decreased number of bacteria in P. aeruginosa infected mice livers, as compared with the control group, was demonstrated. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 20 REFERENCES
Cat's claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection.
TLDR
The primary mechanism for cat's claw anti-inflammatory actions appears to be immunomodulation via suppression of TNFalpha synthesis, which is an effective antioxidant but perhaps more importantly a remarkably potent inhibitor of T NFalpha production. Expand
Uncaria tomentosa (Willd.) DC.--ethnomedicinal use and new pharmacological, toxicological and botanical results.
TLDR
The medicinal system of the Asháninka Indians in Perú is portrayed and a significant normalization of lymphocyte percentage was observed in vivo although total leucocyte numbers did not change. Expand
Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (uña de gato)
TLDR
Two extracts of different collections of the traditional medicine uña de gato from Peru were characterized by High Pressure Liquid Chromatography as containing approximately 6 mg/g total oxindole content prior to studies with alveolar macrophages, suggesting a strong immunostimulant action of this plant. Expand
Anti-inflammatory active polyacetylenes from Bidens campylotheca.
TLDR
Five polyacetylenes, heptadeca-2E,8E,10E,16-tetraene-4,6-diyne-10-ol, and, as a new compound, safynol-2-O-isobutyrate could be isolated and their structures elucidated mainly by UV, MS, NMR, and COSY-NMR. Expand
Plant metabolites. Structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda.
TLDR
A reinvestigation of the bark of Uncaria tomentosa afforded, in addition to the major quinovic acid glycosides 1-3, three further glycoside 4-6, which were elucidated by spectral and chemical studies and a series of antiviral tests were performed. Expand
Anti-inflammatory testing methods: comparative evaluation of mice and rats.
TLDR
It is found that mice, instead of rats, can be used for the anti-inflammatory screening methods and aspirin inhibited the carrageenin, formalin-induced edema, cotton pellet granuloma and adjuvant arthritis apparently. Expand
Die Alkaloide von Uncaria tomentosa und ihre Phagozytose-steigernde Wirkung.
TLDR
With the exception of mitraphyllin and rynchophyllin all alkaloids showed a pronounced enhancement effect on phagozytosis, determined in two IN VITRO tests and the IN VIVO-carbon clearance test. Expand
Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor.
TLDR
Tetracyclic oxindole alkaloids dose-dependently reduce the activity of pentacyclo oxindoles alkaloid on human endothelial cells and proliferation was inhibited significantly while cell viability was not affected. Expand
Antiinflammatory actions of cat’s claw: the role of NF‐κB
Uncaria tomentosa is a vine commonly known as cat’s claw or ‘uña de gato’ (UG) and is used in traditional Peruvian medicine for the treatment of a wide range of health problems, particularlyExpand
Alkaloids of peruvian Uncaria tomentosa
TLDR
Seventeen alkaloids were detected and a seasonal variation in the alkaloid content was observed and two chemical types were identified. Expand
...
1
2
...