Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.

@article{Recio2004AntiinflammatoryAO,
  title={Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.},
  author={Mar{\'i}a del Carmen Recio and Maite Prieto and Marina Bonucelli and Cecilia Orsi and Salvador M{\'a}{\~n}ez and Rosa Marfa Giner and Miguel Cerd{\'a}-nicol{\'a}s and J V Rios},
  journal={Planta medica},
  year={2004},
  volume={70 5},
  pages={414-20}
}
Fractionation of an anti-inflammatory extract from Cayaponia tayuya roots yielded two active compounds, identified as 23,24-dihydrocucurbitacin B (1) and cucurbitacin R (2). Both were evaluated for their anti-inflammatory activity on several experimental models of pain and inflammation. In addition, their cytotoxicity and effects on leukotriene B4 (LTB4) formation were evaluated in rat polymorphonuclear leukocytes. Both compounds showed activity in the following models: carrageenan-induced… CONTINUE READING