Anti-inflammatory activity of orpanoxin administered orally and topically to rodents

@article{Brooks2005AntiinflammatoryAO,
  title={Anti-inflammatory activity of orpanoxin administered orally and topically to rodents},
  author={Robert R. Brooks and Kenneth R. Bonk and George Endel Decker and Kim Elaine Miller},
  journal={Agents and Actions},
  year={2005},
  volume={16},
  pages={369-376}
}
  • Robert R. Brooks, Kenneth R. Bonk, +1 author Kim Elaine Miller
  • Published in Agents and Actions 2005
  • Medicine
  • Orpanoxin, a nonsteroidal anti-inflammatory drug (NSAID) lacking gastric ulcerogenic effects in the therapeutic dose range in rats, was compared with six reference NSAIDs for oral activity in the rat paw carrageenim-induced edema assay. Tested NSAIDs were ranked on the basis of oral mg/kg ED50 values: piroxicam, 0.55; orpanoxin, 35.6; diflunisal, 59.6; benoxaprofen, >300; tolmetin sodium, >300; and sulindae, >300. Zomepirac sodium was inactive. Only the three most potent compounds produced… CONTINUE READING

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