Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models.

@article{Marianecci2012AntiinflammatoryAO,
  title={Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models.},
  author={Carlotta Marianecci and Federica Rinaldi and Marica Mastriota and Stefano Pieretti and Elena Trapasso and Donatella Paolino and Maria Carafa},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2012},
  volume={164 1},
  pages={
          17-25
        }
}
  • C. Marianecci, F. Rinaldi, M. Carafa
  • Published 28 November 2012
  • Biology, Chemistry
  • Journal of controlled release : official journal of the Controlled Release Society
Ammonium glycyrrhizinate-loaded niosomes as a potential nanotherapeutic system for anti-inflammatory activity in murine models
TLDR
Nonionic surfactant vesicles containing polysorbate 20, cholesterol, and cholesteryl hemisuccinate at different molar concentrations were used to prepare monoammonium glycyrrhizinate (AG)-loaded NSVs and showed favorable physicochemical properties for in vitro and in vivo administration.
Pivotal role of Acitretin nanovesicular gel for effective treatment of psoriasis: ex vivo–in vivo evaluation study
TLDR
Act nano niosomal gel produced a remarkable enhanced ex vivo permeation profile up to 30 h and significant drug deposition in the viable epidermal–dermal layers compared with those of Act gel, establishing its distinct in vivo antipsoriatic superiority.
Applications of Niosome and Targeting Strategies in the Field of Phyto-Pharmaceuticals : A Review
TLDR
The present work means to audit the principle niosomal approaches utilized for relationship of various medications and the fundamental accomplishments from utilizing this innovation.
AMMONIUM GLYCYRRHIZINATE: A COMPHERENSIVE REVIEW OF ITS TRADITIONAL USE, PHYTOCHEMISTRY, PHARMACOLOGY & SAFETY
TLDR
GA coupled with glycyrrhetinic acid and 18-beta-glycyrrhetic acid was developed in China or Japan as an anti-inflammatory, antiviral, and anti-allergic drug for liver disease.
FORMULATION AND IN VITRO EVALUTION OF DIACEREIN LOADED NIOSOMES
TLDR
It was concluded that it is possible to enhance solubility and ultimately improve bioavailability of the drug by this promising approach.
pH-sensitive niosomes: Effects on cytotoxicity and on inflammation and pain in murine models
TLDR
P pH-sensitive niosomes were stable in the presence of 0 and 10% fetal bovine serum, non-cytotoxic and able to modify IBU or LID pharmacological activity in vivo.
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References

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In vitro and in vivo evaluation of Bola-surfactant containing niosomes for transdermal delivery
TLDR
Experimental data show that Bola-niosomes are characterized by a mean size of ∼400 nm and are able to provide an encapsulation efficiency of 40% with respect to the drug amount used during preparation, and CLSM showed that they were able to promote the intracellular uptake of the delivered substances.
Glycyrrhizic acid and 18β-glycyrrhetinic acid modulate lipopolysaccharide-induced inflammatory response by suppression of NF-κB through PI3K p110δ and p110γ inhibitions.
TLDR
GA and 18βGA may provide an anti-inflammatory effect by attenuating the generation of excessive NO, PGE(2), and ROS and by suppressing the expression of pro-inflammatory genes through the inhibition of NF-κB and PI3K activity.
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TLDR
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Span® and Tween® neutral and pH-sensitive vesicles: Characterization and in vitro skin permeation
TLDR
When niosomes with SP60 and CHEMS were prepared, there was a statistically significant increase of skin permeation of IBU, while TW20 niosome did not show statistically significant differences in Papp values without the influence of the vesicle size and charge.
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