Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938.

  title={Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938.},
  author={Masako Kuno and Nobuo Seki and Susumu Tsujimoto and Isao Nakanishi and Takayoshi Kinoshita and Katsuya Nakamura and Tadashi Terasaka and Nobuya Nishio and Akihiro Sato and Takashi Fujii},
  journal={European journal of pharmacology},
  volume={534 1-3},
Adenosine has anti-inflammatory activity. Adenosine deaminase (EC metabolizes extracellular adenosine, resulting in an exacerbation of inflammation. Consequently, it was hypothesized that adenosine deaminase inhibitors produce anti-inflammatory activity by increasing extracellular adenosine concentration. This group recently developed a non-nucleoside adenosine deaminase inhibitor, FR234938, by using rational structure-based drug design. FR234938 inhibits recombinant human adenosine… CONTINUE READING
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