Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938.

@article{Kuno2006AntiinflammatoryAO,
  title={Anti-inflammatory activity of non-nucleoside adenosine deaminase inhibitor FR234938.},
  author={Masako Kuno and Nobuo Seki and Susumu Tsujimoto and Isao Nakanishi and Takayoshi Kinoshita and Katsuya Nakamura and Tadashi Terasaka and Nobuya Nishio and Akihiro Sato and Takashi Fujii},
  journal={European journal of pharmacology},
  year={2006},
  volume={534 1-3},
  pages={241-9}
}
Adenosine has anti-inflammatory activity. Adenosine deaminase (EC 3.5.4.4) metabolizes extracellular adenosine, resulting in an exacerbation of inflammation. Consequently, it was hypothesized that adenosine deaminase inhibitors produce anti-inflammatory activity by increasing extracellular adenosine concentration. This group recently developed a non-nucleoside adenosine deaminase inhibitor, FR234938, by using rational structure-based drug design. FR234938 inhibits recombinant human adenosine… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS
18 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 18 extracted citations

Similar Papers

Loading similar papers…