Anti-inflammatory activity of inhaled IL-4 receptor-alpha antisense oligonucleotide in mice.

@article{Karras2007AntiinflammatoryAO,
  title={Anti-inflammatory activity of inhaled IL-4 receptor-alpha antisense oligonucleotide in mice.},
  author={James G. Karras and Jeffrey R. Crosby and Mausumee Guha and David Tung and Doreen A Miller and William A. Gaarde and Richard S. Geary and Brett P. Monia and Susan A. Gregory},
  journal={American journal of respiratory cell and molecular biology},
  year={2007},
  volume={36 3},
  pages={
          276-85
        }
}
The Th2 cytokines IL-4 and IL-13 mediate allergic pulmonary inflammation and airways hyperreactivity (AHR) in asthma models through signaling dependent upon the IL-4 receptor-alpha chain (IL-4Ralpha). IL-13 has been further implicated in the overproduction of mucus by the airway epithelium and in lung remodeling that commonly accompanies chronic inflammation. IL-4Ralpha-deficient mice are resistant to allergen-induced asthma, highlighting the therapeutic promise of selective molecular… CONTINUE READING

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