• Corpus ID: 25875945

Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action.

@article{Preethi2009AntiinflammatoryAO,
  title={Anti-inflammatory activity of flower extract of Calendula officinalis Linn. and its possible mechanism of action.},
  author={Korengath Chandran Preethi and Girija Kuttan and Ramadasan Kuttan},
  journal={Indian journal of experimental biology},
  year={2009},
  volume={47 2},
  pages={
          113-20
        }
}
Key ResultCalendula officinalis flower extract possessed significant anti-inflammatory activity against carrageenan and dextran-induced acute paw edema. Oral administration of 250 and 500 mg/kg body weight Calendula extract produced significant inhibition (50.6 and 65.9% respectively) in paw edema of animals induced by carrageenan and 41.9 and 42.4% respectively with inflammation produced by dextran.

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References

SHOWING 1-10 OF 47 REFERENCES

Antioxidant Potential of an Extract of Calendula officinalis. Flowers in Vitro. and in Vivo.

Results indicated Calendula officinalis has significant antioxidant activity in vitro and in vivo.

Comparative effects of the herbal constituent parthenolide (Feverfew) on lipopolysaccharide-induced inflammatory gene expression in murine spleen and liver

Only one gene, IL-6, was modestly suppressed by parthenolide co-exposure which contrasts with many in vitro studies suggesting anti-inflammatory effects of this compound.

Studies on antiinflammatory effect of Cassia tora leaf extract (fam. Leguminosae)

The antiinflammatory effect of the methanol extract of the leaves of Cassia tora was investigated against carrageenin, histamine, serotonin and dextran‐induced rat hind paw oedema. It exhibited

Carrageenin-Induced Edema in Hind Paw of the Rat as an Assay for Antiinflammatory Drugs

  • C. WinterE. RisleyG. Nuss
  • Medicine, Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1962
The potency ratios obtained for aspirin, phenylbutazone and hydrocortisone are fairly close to the ratios of their respective daily doses in the treatment of rheumatic disease.

Evaluation of homeopathy in broiler chickens exposed to live viral vaccines and administered Calendula officinalis extract.

  • E. BarbourV. Sagherian S. Harakeh
  • Biology, Medicine
    Medical science monitor : international medical journal of experimental and clinical research
  • 2004
Calendula officinalis had an immunomodulation effect against three different live viruses in broiler chickens, associated with improvement in body weights.

Antifungal Activity Of Calendula Officinalis

The in vitro antifungal activity of Calendula officinalis flower extracts showed high degree of activity against all test fungi and the inhibitory effects of extracts are comparable with that of standard abtibiotics used.

Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production.

It is demonstrated that AITC and PITC inhibited tumour-specific angiogenesis by downregulating NO and TNF-alpha production.

Inflammation and the mechanism of action of anti‐inflammatory drugs

  • J. VaneR. Botting
  • Medicine, Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1987
H1 histamine antagonists are effective for hay fever and some skin allergies such as urticaria, which indicates the importance of histamine in these conditions.