Anti-inflammatory activity of ethanolic extract of Sargassum sagamianum in RAW 264.7 cells

@article{Kim2013AntiinflammatoryAO,
  title={Anti-inflammatory activity of ethanolic extract of Sargassum sagamianum in RAW 264.7 cells},
  author={Min-Ji Kim and Koth-Bong-Woo-Ri Kim and Da-Hyun Jeong and Dong Hyun Ahn},
  journal={Food Science and Biotechnology},
  year={2013},
  volume={22},
  pages={1113-1120}
}
Aim of the study is to evaluate the antiinflammatory effects of ethanolic extract of the marine brown alga Sargassum sagamianum collected from Yeonhwari coast of Korea. Ethanolic extract of S. sagamianum (SA-E extract) inhibited expression of nitric oxide (NO) and cytokines (IL-6, IL-1β, and TNF-α) as well as inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX)-2 in lipopolysaccharide (LPS)-induced RAW 264.7 cells without affecting cell viability. In addition, the expression of… 
In vitro antiviral, anti-inflammatory, and antioxidant activities of the ethanol extract of Mentha piperita L.
TLDR
Results indicate that Mentha piperitas L. piperita L. leaves might be a good source of medicinal plants and show potential free-radical scavenging activities.
Sargassum sagamianum Extract Alleviates Postprandial Hyperglycemia in Diabetic Mice
TLDR
Results indicate that SSE can be used as an α-glucosidase and α-amylase inhibitor and can delay the absorption of dietary carbohydrates.
Inula britannica fermented with probiotic Weissella cibaria D30 exhibited anti-inflammatory effect and increased viability in RAW 264.7 cells
TLDR
Results indicate that FIB is a potential beneficial bioactive agent for functional foods and reduces the toxicity and increased the anti-inflammatory properties of I. britannica.
Phlorotannins from Fucus vesiculosus: Modulation of Inflammatory Response by Blocking NF-κB Signaling Pathway
TLDR
Some of the mechanistic aspects behind the anti- inflammation capacity of phlorotannins from F. vesiculosus are unveiled, endorsing its use as a possible natural source of anti-inflammatory compounds.
Antioxidative, Anticholinesterase and Anti-Neuroinflammatory Properties of Malaysian Brown and Green Seaweeds
TLDR
An overview of the properties of Malaysian seaweeds in inhibiting oxidative stress, neuroinflammation and cholinesterase enzymes is provided and marine algae have great potential in pharmaceutical and biomedical applications.
Sargassum sagamianum extract protects INS-1 pancreatic β cells against high glucose-induced apoptosis
TLDR
It is suggested that SSE could be useful as a functional food, protecting pancreatic β cells against high glucose-induced oxidative stress and apoptosis, by recovering the cell viability.
Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review
TLDR
This review aims to explore the potential of Sargassum’s anti-inflammatory activity, not only in crude extracts but also in sulfated polysaccharides and purified compounds.
Brown Algae Phlorotannins: A Marine Alternative to Break the Oxidative Stress, Inflammation and Cancer Network
TLDR
The present manuscript revises relevant studies focusing the effects of phlorotannins to counteract the oxidative stress–inflammation network, emphasizing their potential for application in cancer prevention and/or treatment.
...
...

References

SHOWING 1-10 OF 44 REFERENCES
Evaluation of anti-inflammatory effect of fucoxanthin isolated from brown algae in lipopolysaccharide-stimulated RAW 264.7 macrophages.
  • S. HeoW. Yoon Y. Jeon
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2010
Ecklonia cava ethanolic extracts inhibit lipopolysaccharide-induced cyclooxygenase-2 and inducible nitric oxide synthase expression in BV2 microglia via the MAP kinase and NF-kappaB pathways.
  • Won‐Kyo JungYoung-Wook Ahn I. Choi
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2009
Anti‐inflammatory effects of liquiritigenin as a consequence of the inhibition of NF‐κB‐dependent iNOS and proinflammatory cytokines production
TLDR
The effects of liquiritigenin on the induction of inducible NOS (iNOS) and proinflammatory cytokines by lipopolysaccharide (LPS) in Raw264.7 cells, and on paw oedema in rats are investigated.
Effects of Ixeris dentata extract on the production of pro-inflammatory cytokines in the LPS stimulated rat and Raw 264.7 cells
TLDR
Investigation of anti-inflammatory effect of Ixeris dentata ethanol extract in lipopolysaccharide-exposed rats and Raw 264.7 cells found plasma concentrations of IL-, IL-6 and TNF- were lower, but concentration of IL-10 tended to be increased in Ixers dentata-treated groups.
Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells.
Suppression of pro-inflammatory cytokines, iNOS, and COX-2 expression by brown algae Sargassum micracanthum in RAW 264.7 macrophages
TLDR
It is suggested that S. micracanthum extracts may be considered potential anti-inflammatory candidates for topical application and performed MTT assays on human dermal fibroblast cells, as well as primary skin irritation tests, and did not induce any adverse reactions.
Effects of plastoquinones from the brown alga Sargassum micracanthum and a new chromene derivative converted from the plastoquinones on acute gastric lesions in rats.
TLDR
The results suggest that the protection of the mucosa via endogenous prostaglandins might be related to the antiulcer effects of compounds 1, 2, and 3.
S-adenosylmethionine attenuates the lipopolysaccharide-induced expression of the gene for tumour necrosis factor alpha.
TLDR
AdoMet lowered the amount of TNF secreted by LPS-stimulated murine macrophage cells in a dose-dependent manner and inhibited TNF release in RAW cells, indicating that AdoMet administration might exert its hepatoprotective effects at least in part by its inhibitory effect on expression of the gene for TNF.
...
...