Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-κB and MAPK signaling pathways.

  title={Anti-inflammatory activity of coptisine free base in mice through inhibition of NF-$\kappa$B and MAPK signaling pathways.},
  author={Hanbin Chen and Chaodan Luo and Jia-Li Liang and Zhenbiao Zhang and Guosheng Lin and Jiazhen Wu and Cailan Li and Lihua Tan and Xiao-Bo Yang and Ziren Su and Jianhui Xie and Huifang Zeng},
  journal={European journal of pharmacology},

Comparison of anti-inflammatory effects of berberine, and its natural oxidative and reduced derivatives from Rhizoma Coptidis in vitro and in vivo.

  • Cailan LiLihua Tan Z. Su
  • Biology, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 2019

Anti-nociceptive and anti-inflammatory effect of imperatorin: evidences for involvement of COX-2, iNOS, NFκB and inflammatory cytokines

Investigation revealed that anti-nociceptive and anti-inflammatory potential of imperatorin is probably mediated through the attenuation of COX-2, iNOS, NFκB activity and reduction in circulatory cytokines.

Synthesis and Evaluation of Bakuchiol Derivatives as Potent Anti-inflammatory Agents in Vitro and in Vivo.

Bakuchiol, a prenylated phenolic monoterpene derived from the fruit of Psoralen corylifolia L. (Buguzhi), is widely used to treat tumors, viruses, inflammation, and bacterial infections. In this

Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway

This study shows that UTI exerts both anti-inflammatory and anti-oxidative effects by targeting the JNK/NF-κB and PI3K/Akt/Nrf2 pathways.

Inhibition of oxidative stress induced-cytotoxicity by coptisine in V79-4 Chinese hamster lung fibroblasts through the induction of Nrf-2 mediated HO-1 expression

Coptisine can be used as a potential treatment for oxidative stress-related lung disease and zinc protoporphyrin IX, a potent inhibitor of HO-1, attenuated the ROS scavenging and anti-apoptotic effects of coptisine.

Coptisine Alleviates Imiquimod-Induced Psoriasis-like Skin Lesions and Anxiety-like Behavior in Mice

Coptisine might be a potential candidate for psoriasis treatment by improving both disease severity and psychological comorbidities by lowering the levels of inflammatory cytokines TNF-α, IL-17, and IL-22.

Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function

Evidence shows that intestinal inflammation, oxidative stress, and injury of mucosal barrier are closely related to the pathogenesis of ulcerative colitis (UC). Huang-lian-Jie-du Decoction (HLJDD) is



Inhibitory effect of Coptis chinensis on inflammation in LPS-induced endotoxemia.

Protective effect of the methanol extract from Cryptotaenia japonica Hassk. against lipopolysaccharide-induced inflammation in vitro and in vivo

In vitro and in vivo anti-inflammatory activity of CJ methanol extract was tested using lipopolysaccharide (LPS)-induced inflammatory models and its possible underlying mechanisms that involve modulation of IκBα, MAPK, and STAT1 activities were demonstrated.

Coptisine Prevented IL-β-Induced Expression of Inflammatory Mediators in Chondrocytes

Data suggest that coptisine inhibits the IL-1β-induced inflammatory response by suppressing the NF-kB signaling pathway, and may be a potential agent in the treatment of OA.

Anti-Inflammatory and Antinociceptive Properties of Flavonoids from the Fruits of Black Mulberry (Morus nigra L.)

The results demonstrated that TF of black mulberry possess anti-inflammatory and analgesic effects that might correlate to its antioxidant activities and inhibition of pro-inflammatory cytokines.

Anti-inflammatory activity of aqueous extract and bioactive compounds identified from the fruits of Hancornia speciosa Gomes (Apocynaceae)

The first study that demonstrated the anti-inflammatory activity of the extract of H. speciosa fruits against different inflammatory agents in animal models is demonstrated, suggesting that its bioactive molecules, especially rutin and chlorogenic acid are, at least in part, responsible for such activity.