Anti-inflammatory activity of Leontopodium alpinum and its constituents.

  title={Anti-inflammatory activity of Leontopodium alpinum and its constituents.},
  author={Michael J. Dobner and Silvio Sosa and Stefan Schwaiger and Gianmario Altinier and Roberto della Loggia and Nicole C. Kaneider and Hermann Stuppner},
  journal={Planta medica},
  volume={70 6},
The aerial parts and roots of Leontopodium alpinum Cass. (Asteraceae) were investigated for their in vivo topical anti-inflammatory activity using the inhibition of Croton oil-induced ear dermatitis in mice. For both of the plant parts, the dichloromethane extract induced a dose-dependent oedema reduction, being more active than the methanol and 70% aqueous methanol ex-tracts. Moreover, the dichloromethane extract of the aerial parts was more active than that of the roots (ID50 = 221 and 338 pg… CONTINUE READING