Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH.

  title={Anti-inflammatory actions of the neuroimmunomodulator alpha-MSH.},
  author={James M. Lipton and A. Fede Catania},
  journal={Immunology today},
  volume={18 3},
alpha-melanocyte-stimulating hormone (alpha-MSH) is an endogenous neuroimmunomodulatory peptide that inhibits fever and all major forms of experimental inflammation. In humans, concentrations of alpha-MSH are increased at sites of inflammation, and in plasma in inflammatory disorders and after infection of endotoxin. The effects of this 'anti-cytokine' peptide are mediated through alpha-MSH receptors and regulatory circuits in macrophages and neutrophils, and through descending neural anti… CONTINUE READING